![]() ![]() Serial deletion of the endogenous piwi 5 kb intronic region led to a 300 bp region that drove expression. Based on previous reports of PIWI function in maintaining genome integrity in the germline and neural progenitor cells, I investigated the regulation of PIWI expression in the Ciona central nervous system. Our lab’s single-cell RNA transcriptomics data has shown P-element–induced wimpy testis (PIWI) expression in the CNS, including some overlapping expression with the ependymal marker opsin3. Recent research suggested that ependymal cells in the Ciona central nervous system (CNS) may serve as neural stem cells by demonstrating that part of the adult neurons differentiate from these cells. The motile, swimming larvae of Ciona turn into sessile adults via metamorphosis, requiring the regeneration and restructure of cells after reaching maturity. P-element Induced Wimpy Testis (PIWI) Expression in the Central Nervous System of Ciona intestinalis is Moderated by Transcription Factors Otx and BshĬiona intestinalis is an ascidian species that has been a popular subject of research due to its proximity to vertebrates in evolution. Please use this identifier to cite or link to this item: Princeton University Undergraduate Senior Theses, 1924-2022 Princeton University Masters Theses, 2022-2023 Princeton University Doctoral Dissertations, 2011-2023 ![]() Princeton School of Public and International Affairs Liechtenstein Institute on Self-Determination ![]() Lewis-Sigler Institute for Integrative Genomics Department of Slavic Languages and Literatures ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |